CBX-12 is an alphalex conjugate that includes the highly potent topoisomerase I inhibitor exatecan. CBX-12 was selected based on its ground-breaking efficacy and safety profile demonstrated in preclinical studies. CBX-12 has potential synergy with PD-1 inhibitors and other immuno-oncology drugs. Cybrexa plans to publish preclinical data for CBX-12 in the first half of 2020 and to advance the program into the clinic in 2021.
Licensing discussions are ongoing to expand the Cybrexa portfolio with additional development candidates.
Highly potent anti-cancer agents that are unable to be administered as free drug are targeted to tumors with alphalex, creating novel agents that are effective across solid tumor types.
Mediated by proteins such as PARP, ATM, ATR, and DNA-PK, DNA damage response (DDR) pathways detect and repair errors in the genome. DDR inhibitor therapies induce cancer cell death by straining an already deficient repair response. However, DDR inhibitor therapy does not work well outside of DDR deficient cancer types. Approximately 40-50% of all cancer patients are thought to have DDR deficient tumors, although many of the relevant mutations have not yet been characterized.
By enhancing the therapeutic index and enabling combination therapies that were previously limited by their toxicity, alphalex allows expansion into DDR proficient cancer types.