Cybrexa, a spin-out company from Yale University, is developing a new class of cancer therapeutics, looking to identify combinations of chemotherapy and DNA inhibitors to increase efficacy and reduce toxicity in cancer treatment. Abi Millar spoke to the company to find out more about its approach to oncology.
Jan 03, 2019
Cybrexa Therapeutics, a biotechnology company in New Haven’s Science Park, hopes to start a trial in early 2020 to test its first drug, a therapy that targets the cells of solid tumors to prevent damage to healthy tissue. Cybrexa has now identified a lead candidate for the drug, CBX-11, marking a major milestone for the company, president and CEO Per Hellsund said Wednesday.
Read the full article HERE.
Cybrexa Therapeutics, a New Haven, Conn.-based company developing a solid tumor-targeting technology to work with an already-approved PARP inhibitor, said it plans to submit an investigational new drug application for its lead candidate, CBX-11, by the fourth quarter of 2019. A phase I trial evaluating the drug is expected to begin in the first quarter of 2020. If preclinical findings hold, the approach could potentially enhance the therapeutic index of the PARP inhibitor, improve overall survival and limit the toxicities associated with combining PARP inhibitors and DNA-damaging chemotherapy.
CYBREXA: PH-BASED TUMOR TARGETING
By Chris Lieu, Staff Writer
Cybrexa Therapeutics Inc. is developing a targeting technology that taps the pH of the tumor microenvironment to enhance the delivery specificity and decrease the toxicity of small molecule cancer therapies, starting with PARP inhibitors.
Cybrexa uses its alphalex technology to conjugate a cancer agent to a pH-sensitive peptide via an undisclosed linker. The peptide forms a transmembrane α-helix only at a low pH, which occurs in the tumor microenvironment but not normal tissues, and translocates into cells along with its cargo via a non-endocytotic route. Cytoplasmic glutathione cleaves the linker, releasing the free cancer agent inside the cancer cell.
Cybrexa has applied the alphalex technology to PARP inhibitors first because in DNA damage response (DDR)-proficient cancers, PARP inhibitors are most effective in combination with chemotherapy, but the combination leads to toxicities including myelosuppression, nephrotoxicity and hepatotoxicity, said President and CEO Per Hellsund.
View the PDF here.
Nov 23, 2018
Dr. Ranjit Bindra, Cybrexa’s chief scientific adviser, discusses Cybrexa’s technology on Health Professionals Radio:
Aug 22, 2017
“It’s really like a heat-seeking missile toward tumors,” Yale physician-scientist and Cybrexa’s chief scientific adviser, Dr. Ranjit Bindra, tells the Hartford Courant. “I know it sounds over the top but we’re really re-writing the rules of what makes a drug good and what drugs are possible to deliver to humans.”
Dr. Ranjit Bindra, co-founder of Cybrexa, and Per Hellsund, President and CEO, sat down with the Hartford Courant to discuss the venture’s origins and technology. Read the full article (and watch the video) HERE.