open positions
In Vivo Research Scientist
Cybrexa is seeking a self-motivated, energetic and creative biologist with hands-on experience in rodent in vivo experimentation to take part in the development of novel therapeutics in oncology and report to the biology manager. Essential Job Functions and Duties As a Research Scientist, this position will provide in vivo support for the development and characterization …
Continue reading “In Vivo Research Scientist”
SEE DETAIL
In Vivo Research Scientist
Cybrexa is seeking a self-motivated, energetic and creative biologist with hands-on experience in rodent in vivo experimentation to take part in the development of novel therapeutics in oncology and report to the biology manager.
Essential Job Functions and Duties
As a Research Scientist, this position will provide in vivo support for the development and characterization of small molecules. This will involve leading efficacy and PK/PD studies in mouse tumor models of cancer as well as catheterized rats. The Candidate should have extensive experience in performing pharmacology experiments to aid in the design of pre-clinical studies.
Knowledge, Skills and Abilities
- Experience handling and dosing rodents for PK/PD/efficacy experiments
- Experience developing, troubleshooting and validating in vivo assays
- Ability to multitask, document and organize studies in an electronic notebook, and effectively communicate experimental results at meetings
- Ability to collaborate with a multidisciplinary team of scientists
Education/Experience
The candidate should have a BS/MS degree with 5+ years of industry experience in biological sciences, with demonstrated scientific excellence. Previous experience in working drug discovery programs to develop compounds from the pre-clinical to the clinical setting would be preferred but not required.
Bioanalytical Scientist
ROLE SUMMARY Cybrexa Therapeutics is seeking a highly motivated and team-oriented Bioanalytical Scientist to fill a position supporting the in-vivo pharmacology group at Cybrexa Therapeutics. The candidate’s responsibilities will include the quantitative and qualitative characterization of Cybrexa’s portfolio of peptide drug conjugates using LC-MS/MS and/or LC-HRMS. ROLE RESPONSIBILITIES The individual’s core responsibilities include: Serve as …
Continue reading “Bioanalytical Scientist”
SEE DETAIL
Bioanalytical Scientist
ROLE SUMMARY
Cybrexa Therapeutics is seeking a highly motivated and team-oriented Bioanalytical Scientist to fill a position supporting the in-vivo pharmacology group at Cybrexa Therapeutics. The candidate’s responsibilities will include the quantitative and qualitative characterization of Cybrexa’s portfolio of peptide drug conjugates using LC-MS/MS and/or LC-HRMS.
ROLE RESPONSIBILITIES
The individual’s core responsibilities include:
- Serve as a bioanalytical LC-MS/MS subject matter expert for the in-vivo pharmacology team.
- Provide routine support of in-vitro and in-vivo preclinical studies using either LC-MS/MS or LC-HRMS
- Interprets the bioanalytical and scientific data from internal and external work and authoring of data tables and research study reports.
- Develops and qualifies high-throughput and robust LC-MS/MS assays for both small molecules and small peptide drug conjugates (<5kDa)
- Carries out routine sample fortification, preparation and extraction workflows supporting in-vitro and in-vivo preclinical studies using both manual and automated techniques.
- Provide assay details and appropriate documentation in support of IND filings.
- Capable in the routine operation, maintenance, and troubleshooting of automation, chromatographic and mass spectrometry instrumentation.
- Experience working in a regulated bioanalytical laboratory setting (GLP/GCP) and/or CRO would be beneficial.
- Oversight of scientific and logistical aspects of CRO management
QUALIFICATIONS
- PhD degree in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 2 years of relevant experience.
- Master of Science in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 5 years of relevant experience.
- Bachelor of Science in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 8 years of relevant experience.
- General working knowledge of antibody-drug conjugate or peptide conjugate bioanalytical assay workflows and techniques.
- Assist in the development and execution of multiple endpoint assay quantitation from dosed peptide conjugates or cytotoxic payloads.
- Excellent organizational and computer skills. Experience with data analytical tools such as GraphPad Prism
- Excellent written and oral communication skills. Experience with managing CRO support a plus.
- Effectively prioritize and manage multiple tasks.
- Knowledge and implementation of safe laboratory work practices. Experience working with cytotoxic payloads is a plus.
- Flexible approach to allow work in a dynamic, biotechnology team environment.