Animal Care Technician

Cybrexa is seeking an independent and self-motivated full time or part time animal care technician to assist in mouse and rat animal husbandry.

Essential Job Functions and Duties

As an Animal Care Technician, this position will provide routine care to research animals including feeding and watering, monitoring vivarium environmental conditions, observing daily appearances and behaviors of experimental animals, assisting with dosing and collection of blood and other tissues and performing other duties as assigned.

Education/Experience

AA or BS degree in animal science or related science preferred, but not necessary. The candidate should be capable of performing basic animal care duties with guidance, with the ability to be trained to achieve AALAS ALAT certification and effective verbal and written communication capabilities.

In Vitro Research Scientist

Cybrexa is seeking an in vitro lab scientist to provide expertise in developing novel targets for the treatment of solid tumors. The candidate will provide scientific excellence for the In Vitro group by directing and contributing intellectually and practically to translational pharmacology and PK/PD initiatives.

Essential Job Functions and Duties

As a research scientist, this position will provide in vitro support for the development and characterization of small molecules. The scientist will perform the following:

  • Support collaborative biomarker, translational pharmacology and PK/PD initiatives.
  • Support the compound evaluation process by implementing assays designed to determine the biological activity and attributes of synthetic substrate.
  • Support a bridge of continuous evaluation of compounds from biochemical and cellular assays to animal testing – and eventually toward support of clinical candidate programs.
  • Carry out cell culture activities as needed to support experimental procedures and compound evaluation.

Education/Experience

The candidate should have a BS/MS degree with 5+ years of industry experience in the biological sciences, with demonstrated scientific excellence.

Experience in pharmacology and protein biochemistry is a must.

Experience in rodent PK/PD/efficacy experiments is desired, but not required.

 

 

Bioanalytical Scientist

ROLE SUMMARY

Cybrexa Therapeutics is seeking a highly motivated and team-oriented Bioanalytical Scientist to fill a position supporting the in-vivo pharmacology group at Cybrexa Therapeutics.  The candidate’s responsibilities will include the quantitative and qualitative characterization of Cybrexa’s portfolio of peptide drug conjugates using LC-MS/MS and/or LC-HRMS.

ROLE RESPONSIBILITIES

The individual’s core responsibilities include:

  • Serve as a bioanalytical LC-MS/MS subject matter expert for the in-vivo pharmacology team.
  • Provide routine support of in-vitro and in-vivo preclinical studies using either LC-MS/MS or LC-HRMS
  • Interprets the bioanalytical and scientific data from internal and external work and authoring of data tables and research study reports.
  • Develops and qualifies high-throughput and robust LC-MS/MS assays for both small molecules and small peptide drug conjugates (<5kDa)
  • Carries out routine sample fortification, preparation and extraction workflows supporting in-vitro and in-vivo preclinical studies using both manual and automated techniques.
  • Provide assay details and appropriate documentation in support of IND filings.
  • Capable in the routine operation, maintenance, and troubleshooting of automation, chromatographic and mass spectrometry instrumentation.
  • Experience working in a regulated bioanalytical laboratory setting (GLP/GCP) and/or CRO would be beneficial.
  • Oversight of scientific and logistical aspects of CRO management

QUALIFICATIONS

  • PhD degree in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 2 years of relevant experience.
  • Master of Science in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 5 years of relevant experience.
  • Bachelor of Science in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 8 years of relevant experience.
  • General working knowledge of antibody-drug conjugate or peptide conjugate bioanalytical assay workflows and techniques.
  • Assist in the development and execution of multiple endpoint assay quantitation from dosed peptide conjugates or cytotoxic payloads.
  • Excellent organizational and computer skills. Experience with data analytical tools such as GraphPad Prism
  • Excellent written and oral communication skills.  Experience with managing CRO support a plus.
  • Effectively prioritize and manage multiple tasks.
  • Knowledge and implementation of safe laboratory work practices.  Experience working with cytotoxic payloads is a plus.
  • Flexible approach to allow work in a dynamic, biotechnology team environment.

 

In Vivo Research Scientist

Cybrexa is seeking a self-motivated, energetic and creative biologist with hands-on experience in rodent in vivo experimentation to take part in the development of novel therapeutics in oncology and report to the biology manager.

 Essential Job Functions and Duties

 As a Research Scientist, this position will provide in vivo support for the development and characterization of small molecules. This will involve leading efficacy and PK/PD studies in mouse tumor models of cancer as well as catheterized rats.  The Candidate should have extensive experience in performing pharmacology experiments to aid in the design of pre-clinical studies.

Knowledge, Skills and Abilities

  • Experience handling and dosing rodents for PK/PD/efficacy experiments
  • Experience developing, troubleshooting and validating in vivo assays
  • Ability to multitask, document and organize studies in an electronic notebook, and effectively communicate experimental results at meetings
  • Ability to collaborate with a multidisciplinary team of scientists

Education/Experience

The candidate should have a BS/MS degree with 5+ years of industry experience in biological sciences, with demonstrated scientific excellence. Previous experience in working drug discovery programs to develop compounds from the pre-clinical to the clinical setting would be preferred but not required.