Bioanalytical Scientist


Cybrexa Therapeutics is seeking a highly motivated and team-oriented Bioanalytical Scientist to fill a position supporting the in-vivo pharmacology group at Cybrexa Therapeutics.  The candidate’s responsibilities will include the quantitative and qualitative characterization of Cybrexa’s portfolio of peptide drug conjugates using LC-MS/MS and/or LC-HRMS.


The individual’s core responsibilities include:

  • Serve as a bioanalytical LC-MS/MS subject matter expert for the in-vivo pharmacology team.
  • Provide routine support of in-vitro and in-vivo preclinical studies using either LC-MS/MS or LC-HRMS
  • Interprets the bioanalytical and scientific data from internal and external work and authoring of data tables and research study reports.
  • Develops and qualifies high-throughput and robust LC-MS/MS assays for both small molecules and small peptide drug conjugates (<5kDa)
  • Carries out routine sample fortification, preparation and extraction workflows supporting in-vitro and in-vivo preclinical studies using both manual and automated techniques.
  • Provide assay details and appropriate documentation in support of IND filings.
  • Capable in the routine operation, maintenance, and troubleshooting of automation, chromatographic and mass spectrometry instrumentation.
  • Experience working in a regulated bioanalytical laboratory setting (GLP/GCP) and/or CRO would be beneficial.
  • Oversight of scientific and logistical aspects of CRO management


  • PhD degree in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 2 years of relevant experience.
  • Master of Science in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 5 years of relevant experience.
  • Bachelor of Science in relevant field (chemistry, biochemistry, biology, pharmaceutical sciences).+ 8 years of relevant experience.
  • General working knowledge of antibody-drug conjugate or peptide conjugate bioanalytical assay workflows and techniques.
  • Assist in the development and execution of multiple endpoint assay quantitation from dosed peptide conjugates or cytotoxic payloads.
  • Excellent organizational and computer skills. Experience with data analytical tools such as GraphPad Prism
  • Excellent written and oral communication skills.  Experience with managing CRO support a plus.
  • Effectively prioritize and manage multiple tasks.
  • Knowledge and implementation of safe laboratory work practices.  Experience working with cytotoxic payloads is a plus.
  • Flexible approach to allow work in a dynamic, biotechnology team environment.